In a large mixing bowl, combine the ground chicken, Cajun seasoning, egg, breadcrumbs, Worcestershire sauce, garlic powder, onion powder, salt, and black pepper. Mix gently until just combined.

Divide the chicken mixture into four equal portions, shaping each into a patty about ¾ inch thick. Indent the center of each patty to help them cook evenly.

Preheat a grill or cast-iron skillet over medium-high heat and lightly oil the surface.

Cook the patties for about 5-7 minutes on each side, ensuring they reach an internal temperature of 165°F (75°C).

After cooking, let the patties rest for about 5 minutes.

Assemble your burgers on toasted buns with your choice of toppings.